Conformational analysis of natural products

Pseudorotation of furanoses

The pseudorotation of furanoses, in particular ribofuranoses, is often described in terms of pseudorotation angles (Ψ) and puckering (P). The endocyclic torsions (τ) can be approximated using the relationship derived by Altona and Sundaraligam.
τi=P*cos(Ψ+i*4*π/5)
Geometry
PositionSubstituentOrientation
Check for α(down)
C1'
C2'
C3'
Coupling constants
3JH1',H2' Hz
3JH2',H3' Hz
3JH3',H4' Hz